TB-500 commonly refers to a synthetic, N-terminally acetylated fragment derived from amino acids 17–23 of thymosin beta-4. This short sequence, Ac-LKKTETQ, corresponds to a central region associated with actin binding, cell migration and tissue-remodelling processes.
Studied Uses
TB-500 and the related thymosin beta-4 actin-binding region have primarily been investigated in laboratory and preclinical research involving:
- Cell migration and adhesion
- Wound-healing and tissue-remodelling pathways
- Endothelial-cell activity
- Formation of new blood vessels, known as angiogenesis
- Actin regulation and cellular movement
- Muscle and connective-tissue repair processes
Research has found that the central LKKTETQ region of thymosin beta-4 is biologically associated with endothelial-cell migration, angiogenesis and wound-repair activity.
How It Works
The peptide sequence associated with TB-500 comes from the actin-binding region of thymosin beta-4. Actin is a structural protein that helps regulate cell shape, movement and organization.
By interacting with actin-related cellular processes, this region has been studied for its potential influence on cell migration and tissue remodelling. Related thymosin beta-4 research has also demonstrated effects on endothelial-cell movement and vascular development, which are important components of wound repair.
The precise biological activity of an individual TB-500 product may depend on its verified peptide sequence and formulation.
Product Details
Product: TB-500
Strength: 5 mg
Form: Lyophilized powder
Presentation: Single vial




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