Semax is a synthetic heptapeptide with the amino-acid sequence Met-Glu-His-Phe-Pro-Gly-Pro. It combines the ACTH(4–7) fragment with the tripeptide Pro-Gly-Pro and has been investigated for its effects on neurotrophic signalling, cognition and cellular responses to neurological stress.
Studied Uses
Semax has been examined in laboratory, animal and limited human research involving:
- Learning, memory and attention
- Neuroplasticity and neurotrophic-factor signalling
- Cerebral ischemia and stroke-recovery processes
- Neuronal responses to hypoxia and oxidative stress
- Stress-related behaviour
- Neurological gene-expression and immune-signalling pathways
Human studies have examined Semax in healthy volunteers and people recovering from ischemic stroke. Preclinical research has investigated its effects on neuronal survival, cognitive performance and molecular responses following cerebral ischemia.
How It Works
Experimental studies suggest that it influences the brain-derived neurotrophic factor pathway, including increased BDNF expression and activation of its TrkB receptor. This signalling system is involved in neuronal survival, synaptic plasticity, learning and memory.
Research has also associated Semax with changes in nerve growth factor expression and broader regulation of genes involved in neurological signalling, inflammation and cellular responses to ischemic injury.
Product Details
Product: Semax
Strength: 10 mg
Form: Lyophilized powder
Presentation: Single vial
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