Semaglutide is a long-acting analogue of glucagon-like peptide-1, commonly known as GLP-1. It shares approximately 94% sequence similarity with naturally occurring human GLP-1 and has been modified to provide prolonged biological activity.
Studied Uses
Semaglutide has been clinically studied in areas including:
- Type 2 diabetes and blood-glucose regulation
- Obesity and long-term weight management
- Appetite and caloric-intake regulation
- Cardiovascular-risk reduction
- Kidney outcomes in people with type 2 diabetes and chronic kidney disease
- Metabolic and body-composition changes
Authorized semaglutide formulations have specific applications depending on the product, formulation and market. Clinical research has examined its effects on glycaemic control, body weight, cardiovascular outcomes and chronic kidney disease.
How It Works
Semaglutide selectively binds to and activates GLP-1 receptors. When blood-glucose levels are elevated, this signalling increases insulin secretion and reduces glucagon secretion, helping regulate circulating glucose.
GLP-1 receptors are also found in areas of the brain involved in appetite regulation. Their activation can reduce hunger, food intake and overall caloric consumption. Semaglutide also delays early gastric emptying, influencing how quickly food and glucose move from the stomach into the digestive system.
Product Details
Product: Semaglutide
Strength: 5 mg
Form: Lyophilized powder
Presentation: Single vial
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